Shankar got is first opportunity in Notebook (2007).His Anando Brahma which was a box office success. Regarding his role, a critic noted that "Shakalaka Shankar brings the house down when he mimics popular actors and their iconic dialogues to baffle the ghost".
He appeared in several comic roles before debuting as a lead actor with Shambho Shankara (2018). Later that year, he starred in Driver Ramudu, which is yet to release. He considers actor-politician Pawan Kalyan as his role model.
In 2020, Shankar played Ram Gopal Varma in the film Parannageevi. He is again reprising the role in Ram Gopal Varma's biopic. Two more films where Shankar appears in a lead role, Lord Grandfather and Bomma Adirindi - Dimma Tirigindi are also under production